“ The relationship between cancer and genetics seen”

   

“Is cancer hereditary?” This is one of the most frequently asked questions at hospitals. If you have a family member with cancer, you become anxious and worried that it might be hereditary. What is the actual relationship between cancer and heredity? Let’s dig into the truth based on recent studies. 


Is cancer hereditary? 


To conclude, not all cancers are hereditary. However, some cancers can be influenced by genetic factors. It is known that approximately 5-10% of all cancers are caused by genetic factors. 


For example, breast cancer and ovarian cancer are closely related to mutations in the BRCA1 and BRCA2 genes. If you have a problem with these genes, your risk of developing breast cancer is up to 7-10 times higher than that of the general population. 


If you have a family history, does that mean you will definitely get it? 


No! Just because you have a family history doesn’t mean you will definitely get cancer. Genes are just risk factors, and lifestyle, eating habits, and the environment also have a big impact on the development of cancer. 


For example, even among identical twins with the same genes, one gets cancer while the other lives healthily. This is a representative example of how important acquired factors are.


The latest research tells us a story


In 2024, the US National Cancer Institute (NCI) analyzed 20 years of large-scale data and announced **"The ratio of genes and environment to cancer occurrence"


Genetic factors: Approximately 8-12%

Environmental and lifestyle habits: Approximately 60% or more


In addition, as AI-based genome analysis technology advances, **'precision medicine' that predicts and prevents cancer risk based on an individual's genetic information is being actively studied.


If you have a family member with cancer, consider seeking genetic counseling at a hospital. Even without testing, counseling can help you understand your risk factors and the regular checkups you may need.
Above all, maintaining a healthy lifestyle is key. Quit smoking, eat more vegetables, exercise regularly, and stay consistent with checkups. These habits can be more effective than genetics in preventing cancer.


Reference
  1. National Cancer Institute. “Genetics of Cancer” (2024)
    https://www.cancer.gov/about-cancer/causes-prevention/genetics
  2. American Cancer Society. “Inherited Cancer Syndromes” (2024)
    https://www.cancer.org/cancer/cancer-causes/genetics/inherited-cancer-syndromes.html
  3. Nature Genetics. “Polygenic risk scores in cancer prediction” (2023)
    https://www.nature.com/articles/s41588-023-01315-4

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